Cortisol awakening response in patients with psychosis: Systematic review and meta-analysis

M Berger; AK Kraeuter; D Romanik; P Malouf; GP Amminger; Z Sarnyai

Journal article

Cortisol awakening response in patients with psychosis: Systematic review and meta-analysis

M Berger, AK Kraeuter, D Romanik, P Malouf, GP Amminger, Z Sarnyai

Neuroscience and Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

DOI: 10.1016/j.neubiorev.2016.05.027

Abstract

The cortisol awakening response (CAR), defined as the increase in cortisol release in response to waking up, shows associations with social and environmental risk factors of schizophrenia and has been studied as a potential biomarker in schizophrenia. We report a systematic review and meta-analysis of 11 studies and 879 participants focusing on the CAR of patients with schizophrenia, first-episode psychosis, and at-risk mental states. Random-effects meta-analysis showed that CAR is attenuated in patients with psychosis compared to healthy controls (g = -0.426, 95% CI -0.585 to -0.267, p < 0.001, 11 between-group comparisons, n = 879). Subgroup analysis showed flattened CAR in patients with s..

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University of Melbourne Researchers

Maximus Berger Author

Paul Amminger Author

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Funding Acknowledgements

We thank all authors of the included papers who kindly provided additional data, particularly Dr. Marita Pruessner and Prof. Palmiero Monteleone, as well as Dr. Erik Biros, who provided advice with the data analysis and Dr Sandip Kamath for his comments on the manuscript. This work was supported by a JCU Faculty Grant (ZS). MB received salary support from a JCU Postgraduate Research Scholarship. GPA was supported by National Health and Medical Research Council Australia Senior Research Fellowship (ID:1080963)